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    您现在的位置: 论文网 >> 医药学论文 >> 临床医学论文 >> 探讨老年糖尿病患者临床检验尿白蛋白、免疫球蛋白G及β2微球蛋白临床分析论文

    探讨老年糖尿病患者临床检验尿白蛋白、免疫球蛋白G及β2微球蛋白临床分析

    出处:论文网
    时间:2019-09-11

    探讨老年糖尿病患者临床检验尿白蛋白、免疫球蛋白G及β2微球蛋白临床分析

      【中图分类号】R47.3 【文献标识码】A 【文章编号】1005-0019(2019)15--01

      糖尿病是一种以高血糖为症状的代谢类疾病, 主要是由于患者体内胰岛素分泌障碍或者胰岛素生物作用受损而导致发病[1]。糖尿病是一种终身性的慢性代谢疾病, 其病情复杂, 疗程漫长, 目前在医学上还没有彻底根治的技术手段和方法。本研究就尿白蛋白、免疫球蛋白 G及β2微球蛋白在老年糖尿病患者临床检查中的应用效果进行统计分析, 报告如下。

      1 资料与方法

      1. 1 一般资料 选取2014年7月~2015年8月本院收治的老年糖尿病患者30例作为观察组研究对象。其中男16例, 女14例, 年龄58~96岁, 平均年龄(74.93±7.15)岁。另选取30例体检健康者作为对照组, 其中男15例, 女15例, 年龄55~94岁, 平均年龄(73.44±7.67)岁, 两组一般资料比较差异无统计学意义(P>0.05), 具有可比性。

      1. 2 方法 两组均进行尿白蛋白、免疫球蛋白 G以及β2微球蛋白水平生化检测, 具体如下:①两组受检者检查前保持空腹及静息状态;②采集受检者晨起第一次尿液;③将采集的尿液样本采用免疫学实验检测出尿白蛋白、免疫球蛋白 G以及β2微球蛋白水平。

      1. 3 观察指标及评价标准 统计比较两组尿液检测中的尿白蛋白、免疫球蛋白 G以及β2微球蛋白水平。尿检指标水平正常标准为:尿白蛋白<14.8 mg/L, 免疫球蛋白 G<5.45 g/L, β2微球蛋白<154 μg/L, 临床检测指标数值超过正常范围即为阳性。

      1. 4 统计学方法 采用SPSS17.0统计学软件对数据进行统计分析。计量资料以均数±标准差()表示, 采用t檢验;计数资料采用χ2检验。P<0.05表示差异具有统计学意义。

      2 结果

      观察组患者尿检结果中, 尿白蛋白水平(16.28±2.62)mg/L,免疫球蛋白 G水平(14.26±3.97)g/L,β2微球蛋白水平(212.36±12.36)μg/L,均显著高于对照组患者的(7.28±1.29)mg/L、(5.17±1.99)g/L、(108.37±9.36)μg/L, 差异均具有统计学意义(P<0.05)。

      3 讨论

      糖尿病是临床上一种十分常见的慢性终身性代谢综合征疾病, 主要是由于患者体内的胰岛素分泌功能出现障碍性受损, 导致的一组以高血糖量为特征的新陈代谢性疾病, 具有病情复杂、治愈困难、疗程漫长以及发病率高等特点[2]。糖尿病的致病机制较为复杂, 医学上尚未有明确结论, 其致病因素主要有遗传、年龄、种族以及患者的生活方式等。到目前为止, 遗传、年龄与种族等因素医学上还无法控制, 但是可以对环境以及人们的生活方式进行干预, 以降低糖尿病的发病几率。老年糖尿病患者由于机体代谢功能低下, 体内多个组织器官出现功能性弱化, 再加上体内脂肪、蛋白质的流失, 一般会伴有身体内部脏器的功能性衰退, 导致出现血管、心脏、肾脏以及眼睛等重要器官的损伤, 严重影响患者的生命健康安全。研究表明, 糖尿病由于胰岛素分泌异常所致, 而胰岛素是由β2微球蛋白细胞合成和分泌, 同患者体内的特异受体相结合引发代谢循环, 整个过程中任意环节出现异常都会引起糖尿病的发生[3]。早期及时有效的诊断、治疗和护理干预对于控制糖尿病疾病的进一步发展具有极重大的意义, 可以有效控制患者血糖的继续升高, 调整患者的不良饮食习惯, 预防糖尿病并发症进一步侵害患者的生命健康。尿白蛋白、免疫球蛋白 G以及β2微球蛋白的指标水平含量同糖尿病病症密切相关, 病情严重程度越高, 尿白蛋白、免疫球蛋白 G以及β2微球蛋白的含量就越高, 临床中具有比较高的诊断参考指标意义。

      本研究结果显示, 观察组患者尿白蛋白、免疫球蛋白 G以及β2微球蛋白水平较对照组患者高, 差异有统计学意义(P<0.05), 说明尿白蛋白、免疫球蛋白 G以及β2微球蛋白水平与糖尿病关联密切, 具有较高的特异性和准确性, 可以作为临床糖尿病诊断和检查的参考依据。

      综上所述, 老年糖尿病患者病情同尿液中的尿白蛋白、免疫球蛋白 G以及β2微球蛋白水平关系密切, 可以作为早期病情诊断与检查的依据和参考指标, 临床应用效果明显, 值得临床应用和推广。

    探讨老年糖尿病患者临床检验尿白蛋白、免疫球蛋白G及β2微球蛋白临床分析

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